Haemoglobin-H Disease

Haemoglobin-H disease.

Liver in haemoglobin H disease.

There have been no published reports on the liver of patients with haemoglobin H disease. In 11 Chinese patients studied (six male and five female) with haemoglobin H disease hepatic function and histology were studied. Liver function was normal in all cases; however, the gamma globulin level was raised in four cases, the increase being mainly in IgG in all cases and IgA in six cases. Liver his...

Clinical phenotype of haemoglobin Q-H disease.

Seven patients of Chinese origin who had haemoglobin (Hb) Q-H disease were studied. They were found to have a similar clinical phenotype to that of patients with deletional Hb H disease, who have a near identical genotypic configuration. The complete absence of Hb A in Hb Q-H disease and the similar clinical phenotype to deletional Hb H disease lends support to the observation that Hb Q-Thailan...

Haemoglobin H Disease in an English Family.

Thalassaemia is a hereditary anaemia of widespread geographical distribution with marked variation in clinical severity. Morphological changes in the erythrocytes include microcytosis, anisopoikilocytosis, and the presence of target cells, while an increase in erythrocytic osmotic resistance is characteristic. The haemoglobin content of the erythrocytes is reduced and the present aetiological c...

Haemoglobin H disease in Arabs in Kuwait.

Three cases of haemoglobin H disease are described in Arabs, two of Syrian and one of Kuwaiti origin. Two were investigated on account of moderate anaemia, the third for splenomegaly not associated with anaemia.